Neurocirugía Neurocirugía
Efectos de la administración de dexametasona sobre un modelo experimental de tumor neuroectodérmico primitivo
M. Zurita, S. Oya, S. Coca, J. Vaquero
Laboratorio de Neuro-oncología experimental, Servicio de Neurocirugía, Hospital Universitario Clínica Puerta de Hierro; Departamentos de Biología Celular y Anatomía Patológica, Facultad de Medicina, Universidad Complutense, Madrid
Resumen

Se ha realizado un estudio experimental sobre el tumor IL-7, implantado subcutáneamente en ratas Wistar, al objeto de verificar si la administración sistémica o intralesional de dexametasona puede ejercer un efecto antitumoral. Los resultados obtenidos muestran que, tras cuatro semanas de tratamiento, la administración de este fármaco, ya sea por vía sistémica o mediante inyección directa intratumoral, no modifica significativamente el volumen del tumor ni el índice de proliferación celular. Teniendo en cuenta el carácter neuroectodérmico primitivo del tumor IL-7, los presentes resultados sugieren la ineficacia de la dexametasona, como agente citolítico, sobre neoplasias cerebrales humanas que muestren características histológicas de tumor neuroectodérmico primitivo.

Summary

An experimental study has been performed on the IL-7 tumor growing in the subcutaneous tissue of Wistar rats. The possibility of an antitumor effect of dexamethasone, after systemic or intralesional administration was evaluated. After four weeks of dexamethasone administration, a reduction in the tumor volume or proliferation cell index was not reached. Due to the fact that IL-7 may be considered as a primitive neuroectodermal tumor, our present results suggest that dexamethasone is inefficacious as a cytolytic agent for the control of human primitive neuroectodermal tumors.

Key Words
Primitive neuroectodermal tumor, Dexamethasone, Experimental brain tumor
Palabras Clave
Tumor neuroectodérmico primitivo, Dexametasona, Tumor cerebral experimental
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Zurita, M.; Oya, S.; Coca, S.; Vaquero, J.: Efectos de la administración de dexametasona sobre un modelo experimental de tumor neuroectodérrnico primitivo. Neurocirugía 1996; 7: 189–192.

Copyright © 1996. Sociedad Española de Neurocirugía